MC	<p>aef7_0382</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b08c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b08c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3ed6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3ed6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a469' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a469");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3aa1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3aa1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4449' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4449");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6a3f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6a3f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4341_bcea</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3d4c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3d4c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7ca6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7ca6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bdb2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bdb2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0d36' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0d36");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6b4b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6b4b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8148' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8148");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>cf67_6a3c</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_460c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_460c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ebc2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ebc2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_81aa' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_81aa");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_00d6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_00d6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6a03' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6a03");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b144' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b144");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>1cad_aefd</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ee55' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ee55");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_36ed' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_36ed");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4fa9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4fa9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0289' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0289");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_354f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_354f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f0a8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f0a8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4fab_f990</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3d4a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3d4a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dfae' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dfae");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_289c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_289c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bfed' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bfed");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_84df' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_84df");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4dad' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4dad");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>7fc3_8be7</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c06d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c06d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3b41' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3b41");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7b4d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7b4d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6860' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6860");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f0ac' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f0ac");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_81c3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_81c3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2618_3416</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e6f6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e6f6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d504' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d504");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bb2d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bb2d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b6af' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b6af");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_51cb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_51cb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1a4d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1a4d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>b663_d136</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8947' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8947");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6cde' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6cde");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f895' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f895");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_21af' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_21af");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_306f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_306f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ca97' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ca97");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>aceb_6dc1</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5aef' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5aef");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d1ba' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d1ba");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_63a6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_63a6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ada2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ada2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3577' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3577");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5ae5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5ae5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>29e0_1d30</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_26ca' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_26ca");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bab1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bab1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c768' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c768");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_517c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_517c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9cee' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9cee");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cdc0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cdc0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>eb71_cde3</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_41ff' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_41ff");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0022' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0022");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3bf6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3bf6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5050' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5050");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bc28' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bc28");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_218a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_218a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ecaa_5f03</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8468' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8468");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f607' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f607");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e8a0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e8a0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4625' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4625");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7f52' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7f52");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_31e8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_31e8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>f43e_162a</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_95b3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_95b3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8f95' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8f95");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4aa8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4aa8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8bc7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8bc7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_eee2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_eee2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4b63' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4b63");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>9167_a974</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_eb75' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_eb75");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3a49' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3a49");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa3f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa3f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_493c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_493c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ca2b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ca2b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2156' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2156");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>3957_296d</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4109' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4109");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f458' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f458");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_81ff' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_81ff");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cbb7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cbb7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cd0a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cd0a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_07c9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_07c9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>e14e_9506</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_41ce' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_41ce");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e4b5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e4b5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ccc9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ccc9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6455' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6455");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3e61' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3e61");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_23d5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_23d5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>6f74_fc69</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8c2c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8c2c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0360' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0360");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b789' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b789");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_54eb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_54eb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9eb1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9eb1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0e54' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0e54");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>6bbd_96e8</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_276b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_276b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_354f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_354f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9d5e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9d5e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2d0b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2d0b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c216' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c216");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2f01' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2f01");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>0ee4_1925</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0ff4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0ff4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_564b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_564b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5fc5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5fc5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4834' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4834");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9a0f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9a0f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_77bf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_77bf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>424f_f1fb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6d3c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6d3c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5d09' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5d09");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_474d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_474d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa74' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa74");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9948' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9948");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e2c2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e2c2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>3f60_a9e7</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2f20' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2f20");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3c0d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3c0d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f3c2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f3c2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3a3c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3a3c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1710' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1710");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_87dd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_87dd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>1e53_38e5</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6927' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6927");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b1cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b1cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9363' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9363");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4c5c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4c5c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a8df' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a8df");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c09d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c09d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2b1e_36d8</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ca8d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ca8d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a4c5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a4c5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_26d6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_26d6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f456' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f456");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7df9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7df9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_423e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_423e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>f0f7_c612</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2341' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2341");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7fa6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7fa6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ba6c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ba6c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f6db' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f6db");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e529' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e529");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d1fc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d1fc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>5a39_6a6f</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b6c9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b6c9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_28cb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_28cb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c12c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c12c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_49cb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_49cb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1c3a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1c3a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c2c2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c2c2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>3368_18f9</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_154f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_154f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6ecc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6ecc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3338' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3338");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1f96' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1f96");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f655' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f655");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4cec' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4cec");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>fe01_0036</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a82b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a82b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9cdf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9cdf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_78a3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_78a3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d9d9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d9d9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_37ac' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_37ac");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a32e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a32e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>8bef_b015</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_54c2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_54c2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4ad3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4ad3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_11f1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_11f1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ed14' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ed14");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ad2e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ad2e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fd7b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fd7b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4053_17bb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ac95' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ac95");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a032' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a032");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_20f6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_20f6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_33f7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_33f7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_97f1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_97f1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d66e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d66e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>a0e3_791a</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dea4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dea4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7448' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7448");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d058' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d058");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c8b1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c8b1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0823' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0823");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b802' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b802");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>cd7b_b4be</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b42e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b42e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_137d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_137d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c5c1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c5c1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b3f1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b3f1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3ab9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3ab9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0566' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0566");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c38d_7964</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0bb0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0bb0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_15bb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_15bb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_83c6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_83c6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3e31' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3e31");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ba22' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ba22");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d2eb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d2eb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>67b5_0b07</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6f8f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6f8f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_613a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_613a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4e24' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4e24");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4571' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4571");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dd17' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dd17");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ff5a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ff5a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>a4c8_1683</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6dd0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6dd0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4bbf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4bbf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0fc8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0fc8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f8bd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f8bd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_64ad' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_64ad");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3590' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3590");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4478_0432</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c22a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c22a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4ed0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4ed0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0e27' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0e27");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d0b4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d0b4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9f88' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9f88");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a15e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a15e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ea9d_d84b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c310' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c310");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0739' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0739");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_842d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_842d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b1b9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b1b9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8e5c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8e5c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_36d7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_36d7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>6c66_bef5</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b850' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b850");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_49cf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_49cf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_db33' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_db33");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ba5d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ba5d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_64bd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_64bd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_51e2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_51e2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2716_fbbf</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ba97' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ba97");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f7b7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f7b7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_07f5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_07f5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7d83' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7d83");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_22d2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_22d2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0387' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0387");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c744_09e4</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5992' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5992");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1ab6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1ab6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1d56' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1d56");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ca17' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ca17");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bee3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bee3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d01d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d01d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>bea2_6fd8</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d207' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d207");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bcc6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bcc6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1901' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1901");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5726' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5726");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c740' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c740");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa8f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa8f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>5c0e_b33b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_738b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_738b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7124' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7124");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7a24' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7a24");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_38e6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_38e6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cdba' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cdba");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2c66' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2c66");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2121_217b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_17e4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_17e4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_64e5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_64e5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cc15' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cc15");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a1a6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a1a6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3723' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3723");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ada9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ada9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>8f26_877b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a69f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a69f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_10cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_10cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_03d0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_03d0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dae6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dae6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fac1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fac1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fd05' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fd05");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>b2aa_1c29</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_267a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_267a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_49e0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_49e0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a308' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a308");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa07' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa07");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1292' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1292");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bb2d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bb2d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>9d6f_81c3</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d147' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d147");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a301' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a301");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_76cf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_76cf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_414f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_414f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aff6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aff6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c982' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c982");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>cf85_97b9</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_30c8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_30c8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e810' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e810");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_761c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_761c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8c03' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8c03");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5c87' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5c87");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_787b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_787b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ddcc_140c</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1c96' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1c96");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fd2a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fd2a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_66e2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_66e2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8f25' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8f25");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_27c7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_27c7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c51f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c51f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>608c_c7da</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a344' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a344");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7d32' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7d32");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7cc5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7cc5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b310' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b310");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f5e8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f5e8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bd45' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bd45");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>5d00_80a2</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c471' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c471");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1f09' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1f09");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c605' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c605");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_17b8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_17b8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7ef2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7ef2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c1a1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c1a1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>04db_abb5</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_83ce' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_83ce");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5627' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5627");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d536' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d536");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5eed' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5eed");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d8da' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d8da");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6f63' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6f63");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>9069_8eb7</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e4fb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e4fb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6852' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6852");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3467' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3467");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a39a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a39a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8582' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8582");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9bc5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9bc5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>a7da_aed3</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa80' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa80");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8bf9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8bf9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2e5a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2e5a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bfdf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bfdf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4da4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4da4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ddc2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ddc2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>e040_db12</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_02bb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_02bb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1020' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1020");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2a91' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2a91");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_551a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_551a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e173' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e173");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4061' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4061");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>75fc_9939</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0f3b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0f3b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e4e4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e4e4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f484' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f484");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_51cc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_51cc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_00e4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_00e4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_25fb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_25fb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>d6fd_962e</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bd80' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bd80");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_680e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_680e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1e65' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1e65");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9c2e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9c2e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5ebb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5ebb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8e6e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8e6e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>5006_21c0</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_31f0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_31f0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c151' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c151");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6a0d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6a0d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d37b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d37b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_da29' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_da29");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3167' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3167");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>fac8_1d2b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_db86' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_db86");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5b7a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5b7a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_17cb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_17cb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d769' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d769");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a83b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a83b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a664' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a664");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>8911_7a80</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6eb3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6eb3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8a05' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8a05");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_59f1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_59f1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_488c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_488c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3ade' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3ade");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_32b9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_32b9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4870_b848</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ed30' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ed30");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_49f9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_49f9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a26d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a26d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d3d7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d3d7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5054' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5054");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9413' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9413");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>88fd_bb8d</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_96d9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_96d9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f80d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f80d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e3ac' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e3ac");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b8ee' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b8ee");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_58ff' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_58ff");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7925' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7925");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>10a5_8edb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fc53' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fc53");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_520f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_520f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b4c7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b4c7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5ec8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5ec8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9f38' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9f38");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_23bf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_23bf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>3266_d46c</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_43cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_43cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ae7f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ae7f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8945' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8945");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7d0d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7d0d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f2c0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f2c0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3667' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3667");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>4a6c_ab73</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5152' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5152");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2947' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2947");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3f22' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3f22");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_97ec' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_97ec");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3421' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3421");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d53f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d53f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>f836_baba</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2309' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2309");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_74f8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_74f8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_367e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_367e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a5de' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a5de");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7ece' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7ece");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2cd0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2cd0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>7ecd_b800</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_de9e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_de9e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b32c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b32c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_465a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_465a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_13cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_13cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c9e8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c9e8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8b1a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8b1a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c9b2_3f82</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f52b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f52b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_535e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_535e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ba92' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ba92");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5c97' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5c97");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e6ea' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e6ea");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f9c4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f9c4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ab30_c14f</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e1f3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e1f3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_281e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_281e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dda7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dda7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_38c9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_38c9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_934e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_934e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0c0b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0c0b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c283_241b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_76f3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_76f3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f1c6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f1c6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9f01' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9f01");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5829' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5829");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b29c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b29c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f2ea' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f2ea");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>bc5c_40cd</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c9dc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c9dc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e54d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e54d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bb11' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bb11");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_96f3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_96f3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_75e0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_75e0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9860' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9860");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>6d8a_ea73</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d14c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d14c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d703' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d703");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_058a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_058a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_93c4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_93c4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f1da' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f1da");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d135' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d135");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>3859_72bb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5e26' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5e26");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bbbf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bbbf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ef6b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ef6b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b679' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b679");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ac43' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ac43");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4cbe' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4cbe");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>654b_cb83</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0421' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0421");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1821' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1821");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2183' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2183");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1f26' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1f26");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9b33' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9b33");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c069' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c069");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>1b94_c6ee</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2657' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2657");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7813' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7813");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6eab' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6eab");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5ac3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5ac3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2a88' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2a88");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d5c3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d5c3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>1692_faca</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2408' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2408");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9e6d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9e6d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_942f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_942f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5db9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5db9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2a22' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2a22");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6b3c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6b3c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>ea7f_89b0</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3a8c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3a8c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5162' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5162");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_996c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_996c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_748c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_748c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_59cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_59cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_01b6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_01b6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>a6d4_3027</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1fca' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1fca");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4ee1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4ee1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5b8e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5b8e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dca2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dca2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_be28' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_be28");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_93d3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_93d3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2d29_abf1</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f4e6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f4e6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f385' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f385");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a7e2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a7e2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d4a2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d4a2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b16f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b16f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d228' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d228");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>dbfb_c3be</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4a5f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4a5f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9c12' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9c12");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d887' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d887");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b506' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b506");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2265' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2265");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3d60' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3d60");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>23df_767f</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_df8c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_df8c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f73b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f73b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4620' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4620");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c884' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c884");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bfb2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bfb2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_51f0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_51f0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>82c2_1507</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1d28' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1d28");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_09b2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_09b2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_77f0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_77f0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_55a2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_55a2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_00ce' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_00ce");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bc50' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bc50");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>9a56_3095</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3297' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3297");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0cb0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0cb0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6338' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6338");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a04c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a04c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cd2c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cd2c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_56b1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_56b1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>79f4_6099</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 12.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8170' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8170");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dca6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dca6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_77c1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_77c1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9bc8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9bc8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_79b3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_79b3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8b2b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8b2b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>2bfc_1d21</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fa30' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fa30");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fcfd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fcfd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_46c9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_46c9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b62c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b62c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_caa5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_caa5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9352' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9352");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ff0f_4cfb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d957' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d957");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_27b7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_27b7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c8fa' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c8fa");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b3bb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b3bb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8ad1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8ad1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0725' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0725");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>1a9a_3a47</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cd56' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cd56");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_759e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_759e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f191' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f191");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d931' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d931");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cac7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cac7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_be62' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_be62");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>05d5_be6a</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_173d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_173d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_66af' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_66af");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8cc0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8cc0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a213' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a213");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e254' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e254");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7c51' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7c51");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>497e_b092</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_08b5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_08b5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0c25' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0c25");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0711' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0711");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4122' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4122");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1f77' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1f77");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7008' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7008");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>21c3_1244</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0f18' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0f18");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9bbf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9bbf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6d81' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6d81");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a6ad' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a6ad");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9d93' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9d93");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5c69' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5c69");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>b99b_4b82</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e6d3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e6d3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_715e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_715e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3b5c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3b5c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c2fa' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c2fa");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1bc9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1bc9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_070b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_070b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>dcc2_7dc6</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 2.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7ce3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7ce3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4e5e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4e5e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0f5e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0f5e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f80c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f80c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0134' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0134");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ea2f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ea2f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>6182_a846</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.2</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_27cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_27cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_24d4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_24d4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ebd5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ebd5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_834c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_834c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b23a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b23a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1bd6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1bd6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>0439_0611</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b289' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b289");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_65b7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_65b7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_61ca' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_61ca");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0e8c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0e8c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9b4a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9b4a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c4d7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c4d7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>832e_fc36</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2e36' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2e36");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f1c0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f1c0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_75cc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_75cc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ac28' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ac28");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d5bc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d5bc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d8d3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d8d3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>0fea_f5b4</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f016' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f016");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9ad3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9ad3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f457' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f457");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_edc4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_edc4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_052d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_052d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_da8c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_da8c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>ade5_569a</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.7</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9723' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9723");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2026' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2026");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7e6d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7e6d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_67e8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_67e8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7032' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7032");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9edd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9edd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>74f2_cade</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2143' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2143");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6621' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6621");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5f30' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5f30");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f3ad' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f3ad");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3e7c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3e7c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b065' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b065");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>5631_6555</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b5d1' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b5d1");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_88ed' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_88ed");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4bc9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4bc9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0d01' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0d01");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5949' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5949");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_abc3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_abc3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>9b58_d08c</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 4.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b4db' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b4db");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_e5f9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_e5f9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_126f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_126f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2a6d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2a6d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7528' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7528");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_26db' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_26db");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>d7f3_ee81</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_692f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_692f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_281b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_281b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_121d' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_121d");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_09bf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_09bf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_cc3a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_cc3a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_40e7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_40e7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c558_9a8d</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 5.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3400' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3400");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c237' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c237");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2d18' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2d18");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6635' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6635");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4c60' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4c60");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3338' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3338");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>0e06_f959</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a681' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a681");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5335' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5335");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5658' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5658");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_feda' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_feda");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0cbf' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0cbf");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7f53' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7f53");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>020e_7951</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_db98' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_db98");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8983' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8983");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_fa6a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_fa6a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b8dd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b8dd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a8de' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a8de");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b321' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b321");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>0831_b5cb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9d5f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9d5f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_15ba' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_15ba");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_753f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_753f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d9ab' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d9ab");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a0d8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a0d8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6362' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6362");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct
MC	<p>58c7_a101</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_34d3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_34d3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d039' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d039");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d787' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d787");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b8f5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b8f5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dc3c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dc3c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_17e5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_17e5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>c5ba_c060</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 11.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f931' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f931");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b6b6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b6b6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3d66' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3d66");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_ab79' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_ab79");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_aa81' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_aa81");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_dfc0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_dfc0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>b895_99ed</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1264' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1264");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_26b9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_26b9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7d0c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7d0c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_769f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_769f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bf36' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bf36");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0928' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0928");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>e0a2_7d42</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c068' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c068");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_11aa' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_11aa");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_72d4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_72d4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f885' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f885");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_63a2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_63a2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5df9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5df9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>6659_66d4</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 3.8</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_79b2' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_79b2");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3cee' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3cee");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0206' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0206");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c77b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c77b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6b8f' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6b8f");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_3dcb' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_3dcb");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>f209_96d2</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.4</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f10c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f10c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5afe' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5afe");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_c4d6' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_c4d6");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_688c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_688c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_816e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_816e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_bc3b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_bc3b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>e695_dcdc</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 6.9</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a2e4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a2e4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d041' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d041");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f104' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f104");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d9d9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d9d9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_21d9' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_21d9");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1d41' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1d41");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>52f8_daa2</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.5</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6d25' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6d25");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_1be5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_1be5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_7a74' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_7a74");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d9a4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d9a4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4b53' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4b53");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_143b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_143b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>8519_3c11</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 7.3</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_523c' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_523c");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_baa8' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_baa8");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5464' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5464");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_d32b' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_d32b");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_34e7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_34e7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f4cd' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f4cd");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>8417_2680</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 1.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b41e' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b41e");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2f24' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2f24");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_07cc' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_07cc");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_de06' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_de06");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9fde' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9fde");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9e47' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9e47");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>b49d_4ccb</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 10.1</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_9bd0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_9bd0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_0593' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_0593");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_91b4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_91b4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6ae3' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6ae3");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_de32' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_de32");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5fc5' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5fc5");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>81d0_dc38</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 9.6</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f15a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f15a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_b8f7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_b8f7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_13d0' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_13d0");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_2485' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_2485");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_8002' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_8002");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_f681' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_f681");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect
MC	<p>146c_5c2b</p> <script src="https://unpkg.com/@rdkit/rdkit/dist/RDKit_minimal.js"></script><h3>Histidine Protonation States</h3><p>Histidine has three pKa values: 1.82, 6.00, and 9.17.</p><p><strong>Question:</strong> Which one of the following is the correct protonation state of histidine at <span style='color:#0066cc;font-size:1.35em;font-weight:700;background-color:#e6f2ff;padding:0.1em 0.4em;border-radius:4px;'>pH 8.0</span>?</p><p>Select one answer.</p>	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>A. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_af00' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_af00");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Correct	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>B. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_4ec4' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CN=C([NH]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_4ec4");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>C. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_55d7' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_55d7");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>D. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_5fde' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>2</sub></strong><br/>Imidazole: <strong>NH and N</strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=CNC=C1C[C@@H](C(=O)O)N";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_5fde");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>E. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_6f7a' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COOH</strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)O)[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_6f7a");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect	<div style='border:1px solid #ddd;border-radius:8px;padding:0.8em;'>F. <div style='display:flex;align-items:center;gap:1.2em;'><div style='flex-shrink:0;'><canvas id='canvas_histidine_a945' width='320' height='240'></canvas></div><div style='flex-grow:1;'><div style='font-size:0.9em;line-height:1.4;'>Carboxyl: <strong>COO<sup>-</sup></strong><br/>Amino: <strong>NH<sub>3</sub><sup>+</sup></strong><br/>Imidazole: <strong>NH and NH<sup>+</sup></strong></div></div></div></div><script>/* */initRDKitModule().then(function(instance){RDKitModule=instance;console.log("RDKit:"+RDKitModule.version());/* */let/* */smiles="C1=C([NH]C=[NH+]1)C[C@@H](C(=O)[O-])[NH3+]";let/* */mol=RDKitModule.get_mol(smiles);let/* */mdetails={};mdetails["explicitMethyl"]=true;canvas=document.getElementById("canvas_histidine_a945");mol.draw_to_canvas_with_highlights(canvas,JSON.stringify(mdetails));});/* */</script>	Incorrect