be5a_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCca9d_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have neither HemA nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC4bb8_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC50aa_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC7adb_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC42dd_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both color blindness and HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCecde_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4fff_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither AIS nor achondroplasia?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC69d1_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and HD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4f9b_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCec27_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HemA but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe09c_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have HD but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCea75_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both DMD and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCd8cb_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither DMD nor MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC0780_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have color blindness but not achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC3192_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC6c38_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not HemA?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC835d_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have achondroplasia but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCf446_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC69d0_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have MFS but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCd1f1_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither HemA nor achondroplasia?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC5171_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not color blindness?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe2db_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have both HemA and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC2395_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both DMD and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9aca_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC589c_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have neither HemA nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC85ee_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither DMD nor MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCbbb7_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) has DMD; her father has DMD as well. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither DMD nor MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC242c_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither AIS nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC68e7_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both color blindness and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCc485_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither HemA nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MCfb73_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither HemA nor achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC6ac2_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have both DMD and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4fb1_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both HemA and achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC8acb_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC210d_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both DMD and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCec63_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither HemA nor achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC38b5_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) has DMD; her father has DMD as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not DMD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC08a2_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) has DMD; her father has DMD as well. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not DMD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCabf8_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have HD but not DMD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC6b76_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have neither AIS nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCa42b_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCf6a3_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have DMD but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb247_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb4c7_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC0a51_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have color blindness but not achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf4ab_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have color blindness but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9abf_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC67d9_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not AIS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCeb0b_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC88bc_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both AIS and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCfd3a_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HemA but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC47f4_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have color blindness but not achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MCbbe4_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe28e_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCbcf8_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have AIS but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9128_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither HemA nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC3126_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf5fa_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not DMD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe6ee_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have both HemA and MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC0749_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have both AIS and achondroplasia?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC73a7_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCc514_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both AIS and MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCc2e8_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC0c08_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC721e_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have HemA but not achondroplasia?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4753_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have AIS but not HD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC1f4b_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) has DMD; her father has DMD as well. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MCcbb8_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have both color blindness and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCbd50_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither DMD nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC7b4f_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC0a16_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both DMD and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4012_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4350_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCae4f_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCd5a6_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both color blindness and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb0fb_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC827b_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC6d0d_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9030_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCd9d7_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC04c8_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCbf81_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MCee56_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not color blindness?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC3ac1_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both AIS and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCdf29_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have both color blindness and achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC3d47_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both AIS and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC430c_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC3e75_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have color blindness but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9584_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4a52_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have DMD but not achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe4fe_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb59a_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have both DMD and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCba0d_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have HemA but not achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCb105_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have AIS but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC6d2e_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not HemA?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC6e40_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe654_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not DMD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MC1c3a_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not DMD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC0f8e_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not color blindness?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC650a_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither color blindness nor MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCeb2b_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither color blindness nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MC9100_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not HemA?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4c03_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not DMD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC176c_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have HemA but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC10f8_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have achondroplasia but not color blindness?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC3e26_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4e8a_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have HemA but not achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCae3d_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have both DMD and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC43ad_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) has DMD; her father has DMD as well. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have achondroplasia but not DMD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCcf4c_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both HemA and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCa87c_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither HemA nor achondroplasia?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4cc6_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have color blindness but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb42b_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither DMD nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC7c74_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have neither DMD nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCd7c1_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not color blindness?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe8ce_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have MFS but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC452b_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have DMD but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe296_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MC1f38_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCa7b3_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither HemA nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC5be1_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC3d3d_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have color blindness but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC7fab_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC20ca_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not color blindness?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC499d_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have neither DMD nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC23b7_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC86ec_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both DMD and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCbfe3_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both HemA and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC2465_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCa99a_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC0d41_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have neither HemA nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCe8a4_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both AIS and HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCdec7_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not HemA?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf713_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have HD but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCf771_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC8455_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC2afd_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not HemA?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC4bfb_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: HemA is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have HemA but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC6a9c_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9661_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf133_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCeaf8_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC99a1_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have both HemA and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC7aa1_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and HD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC83b8_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have neither color blindness nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCeedf_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC9e21_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCe513_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC03d3_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither DMD nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC6f65_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both color blindness and MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MCb648_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither DMD nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCabc3_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC253a_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither color blindness nor MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCc699_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC05d9_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not DMD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf0ba_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) has HD. The father (♂) of the man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither HemA nor HD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCfc8b_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC3b03_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. Genetic testing shows the woman (♀) is not a carrier for HemA. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: HemA is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have both HemA and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCb8d6_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC9515_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCfbc3_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC3033_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) is a carrier for color blindness; her father has color blindness, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have both color blindness and MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9b25_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have HD but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC55c5_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCac77_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) has HD. The mother (♀) of the man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have AIS but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC255d_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have MFS but not AIS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC9e34_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC6c23_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both AIS and MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC28cf_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither color blindness nor MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC26ce_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: color blindness is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCe21d_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have both AIS and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC071f_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have HD but not HemA?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC6ced_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MCe27c_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have MFS but not color blindness?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf099_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have achondroplasia but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCd49e_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have MFS but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect MC1be2_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. The woman (♀) has color blindness; her father has color blindness as well. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have color blindness but not MFS?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCb366_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have neither AIS nor MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4381_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: color blindness is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have color blindness but not achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCaebd_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have HemA. The woman (♀) is a carrier for HemA; her father has HemA, but her mother does not. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HemA but not HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCc19f_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have MFS but not AIS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCf14d_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have neither DMD nor achondroplasia?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC25ce_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has achondroplasia. The father (♂) of the man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have DMD but not achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCa3b0_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have neither AIS nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Correct MC2aa5_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have both AIS and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC4c35_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The mother (♀) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not AIS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC101e_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their daughters (♀) will have achondroplasia but not DMD?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe639_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. The woman (♀) has AIS; her father has AIS as well. The man (♂) has achondroplasia. The mother (♀) of the man (♂) does not have achondroplasia. The woman (♀) has achondroplasia. The father (♂) of the woman (♀) does not have achondroplasia.
Reminder: AIS is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have neither AIS nor achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCfa7e_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. The woman (♀) is a carrier for DMD; her father has DMD, but her mother does not. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their sons (♂) will have DMD but not MFS?
None, 0% Incorrect 1/4, 25% Correct 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC8dd2_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has MFS. The mother (♀) of the man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have DMD but not MFS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCe986_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither DMD nor HD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MC70ae_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have HD. The woman (♀) has HD. The father (♂) of the woman (♀) does not have HD.
Reminder: DMD is X-linked recessive and HD is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have both DMD and HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC26dc_e69f
Hemophilia A (HemA) is an X-linked recessive genetic disorder that is caused by a mutation in the HEMA gene. This results in blood cannot clot properly due to a deficiency of a clotting factor. The disorder affects 1 in 1,000 American males. Individuals affected with HemA have prolonged bleeding from common injuries. The defective gene for HemA is located on the long arm of chromosome X at position 28.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) has HemA. The woman (♀) has HemA; her father has HemA as well. The man (♂) does not have HD. The woman (♀) has HD. The mother (♀) of the woman (♀) does not have HD.
Reminder: HemA is X-linked recessive and HD is autosomal dominant.
What fraction of their sons (♂) will have neither HemA nor HD?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCfd00_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Achondroplasia is an autosomal dominant genetic disorder that is caused by a mutation in the FGFR3 gene. This results in a mutated protein that interacts negatively with growth factors leading to complications with bone production. The disorder affects 1 in 27,500 people. Individuals affected with achondroplasia have dwarfism with short arms and legs, an enlarged head, and a prominent forehead. The defective gene for achondroplasia is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) does not have achondroplasia. The woman (♀) does not have achondroplasia.
Reminder: DMD is X-linked recessive and achondroplasia is autosomal dominant.
What fraction of their sons (♂) will have both DMD and achondroplasia?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MCbfc7_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Huntington's disease (HD) is an autosomal dominant genetic disorder that is caused by an increase in trinucleotide repeats in the HTT gene. This results in a mutated Huntington protein that is toxic to certain cell types, particularly brain cells. The disorder affects 1 in 10,000 adults of European descent. Individuals affected with HD have physical abilities that gradually worsen and mental abilities that decline into dementia. The defective gene for HD is located on the short arm of chromosome 4 at position 16.3.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have AIS. The woman (♀) is a carrier for AIS; her father has AIS, but her mother does not. The man (♂) does not have HD. The woman (♀) does not have HD.
Reminder: AIS is X-linked recessive and HD is autosomal dominant.
What fraction of their daughters (♀) will have HD but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC8a7f_e69f
Deuteranomaly red-green color blindness is an X-linked recessive genetic disorder that is caused by mutations in the OPN1MW gene. This results in shift in the green retinal receptors toward red wavelength sensitivity. The disorder affects 1 in 20 males and 1 in 400 females of Northern European ancestry. Individuals affected with color blindness have decreased ability to see colors in which they are unable distinguish between shades of red and green. The defective gene for color blindness is located on the long arm of chromosome X at position 28.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have color blindness. Genetic testing shows the woman (♀) is not a carrier for color blindness. The man (♂) does not have MFS. The woman (♀) has MFS. The father (♂) of the woman (♀) does not have MFS.
Reminder: color blindness is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have MFS but not color blindness?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Correct 3/4, 75% Incorrect All, 100% Incorrect MCf9f2_e69f
Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic disorder that is caused by a mutation in the AR gene for the human androgen receptor. This results in partial or complete inability of cells to respond to androgens. The disorder affects 1 in 20,000. Individuals affected with AIS have impaired development of male genitals and male secondary sexual characteristics at puberty. The defective gene for AIS is located on the long arm of chromosome X at position 11.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) has AIS. Genetic testing shows the woman (♀) is not a carrier for AIS. The man (♂) does not have MFS. The woman (♀) does not have MFS.
Reminder: AIS is X-linked recessive and MFS is autosomal dominant.
What fraction of their children (sons and daughters equally likely) will have MFS but not AIS?
None, 0% Correct 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Incorrect All, 100% Incorrect MC01d4_e69f
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder that is caused by mutations in the DMD gene. This results in dystrophin is responsible for connecting the actin cytoskeleton to the extracellular matrix (ECM) in muscle cells. The disorder affects 1 in 20,000 males. Individuals affected with DMD have muscle weakness, trouble standing up, which eventually leads to loss of skeletal muscle control, respiratory failure, and death. The defective gene for DMD is located on the short arm of chromosome X at position 21.2.
Marfan syndrome (MFS) is an autosomal dominant genetic disorder that is caused by a mutation in FBN1 gene that makes fibrillin protein. This results in weaked connective tissue throughout the body. The disorder affects 1 in 10,000 people. Individuals affected with MFS have tall and thin features with serious complications involving the heart and aorta. The defective gene for MFS is located on the long arm of chromosome 15 at position 21.1.
A man (♂) and a woman (♀) are planning a family. The man (♂) does not have DMD. Genetic testing shows the woman (♀) is not a carrier for DMD. The man (♂) has MFS. The father (♂) of the man (♂) does not have MFS. The woman (♀) has MFS. The mother (♀) of the woman (♀) does not have MFS.
Reminder: DMD is X-linked recessive and MFS is autosomal dominant.
What fraction of their daughters (♀) will have MFS but not DMD?
None, 0% Incorrect 1/4, 25% Incorrect 1/2, 50% Incorrect 3/4, 75% Correct All, 100% Incorrect