Topic 4: Proteins: Structure and Folding

Protein folding, structural levels, and mechanisms.

Levels of Protein Structure

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Which one of the following levels of protein structure correspond to the description 'side chain hydrogen bonding between distant amino acids'.

• primary 
• quaternary 
• secondary 
• tertiary 

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Hydrogen Bonding in Alpha-Helix Structures

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The α-helix is a right-handed coil in which each backbone N–H group forms a hydrogen bond with the C=O group of an amino acid located a few residues away. The regular pattern of hydrogen bonding stabilizes the helix, preventing it from unraveling.
In a long α-helix, amino acid number 8 would form a hydrogen bond with which two other amino acids?
Select the correct pair of amino acids below.

• amino acids 7 and 9 (a residue shift of 1 position) 
• amino acids 6 and 10 (a residue shift of 2 positions) 
• amino acids 5 and 11 (a residue shift of 3 positions) 
• amino acids 4 and 12 (a residue shift of 4 positions) 
• amino acids 3 and 13 (a residue shift of 5 positions) 

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Ionic Bond Formation in Amino Acid Side Chains

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Based on the chemical properties of amino acid side chains, which pair of amino acids listed below can form an ionic bond between their side chains?

• Proline and Alanine 
• Histidine and Glutamate 
• Threonine and Aspartate 
• Proline and Histidine 
• Threonine and Methionine 

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