8: RNA Processing and CRISPR

RNA splicing, mRNA maturation, and CRISPR gene editing.

Determining Alternative Splicing Possibilities

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Click to show Determining Alternative Splicing Possibilities example problem

5′ UTR	exon 1 110 bp	intron 2	exon 2 160 bp	intron 3	exon 3 180 bp	intron 4	exon 4 200 bp	3′ UTR
80 bp		170 bp		70 bp		190 bp		90 bp

The eukaryotic pre-mRNA shown above can be alternatively spliced in a number of different ways.

Which one of the following is NOT a possible processed mRNA?

• A.

  5′ cap	exon 2 160 bp	exon 3 180 bp	exon 4 200 bp	polyA tail
  80 bp				120 bp

  
  
• B.

  5′ cap	exon 3 180 bp	exon 1 110 bp	exon 2 160 bp	polyA tail
  80 bp				120 bp

  
  
• C.

  5′ cap	exon 1 110 bp	exon 3 180 bp	exon 4 200 bp	polyA tail
  80 bp				120 bp

  
  
• D.

  5′ cap	exon 1 110 bp	exon 2 160 bp	exon 3 180 bp	polyA tail
  80 bp				120 bp

  
  
• E.

  5′ cap	exon 1 110 bp	exon 2 160 bp	exon 4 200 bp	polyA tail
  80 bp				120 bp

  
  

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